包皮过长和包茎组织中触觉小体观察

目的观察包茎和包皮过长组织中触觉小体差异情况。方法收集21~25岁年龄组包皮标本44例,按包皮解剖形态分为:①包茎组21例;②包皮过长组23例。用免疫组化方法对两组包皮标本中的触觉小体进行染色,在放大100倍的视野下观察和统计两组包皮标本中触觉小体总数以及视野的总数,并用卡方检验对两组间的差异进行统计学分析。结果两组标本中,分别有8个(8/21包茎组)和10个(10/23包皮过长组)标本中未发现触觉小体,其差异无显著性(P=0.717)。包茎组和包皮过长组中触觉小体的密度分别为33.1%和21.1%,差异具显著性(P=0.022)。结论包茎中触觉小体密度较包皮过长明显升高可能是一种生理性代偿机制,而两种包皮组织中触觉小体的消失可能遵循同一规律。     

CO2激光包皮环切"美容"术1624例

目的探讨将整形美容的方法引入CO2激光包皮环切术中治疗包皮过长及包茎的疗效。方法在行常规CO2激光包皮环切术中,将整形美容的方法贯穿始终。结果1624例中,1593例术后未发生并发症,伤口愈合良好,外形美观;7例术后6h内发生出血,24例术后9~20d切口裂开。结论将整形美容的方法引入CO2激光包皮环切术中,伤口愈合良好,外形美观,疗效满意。     

阴茎皮肤和包皮动脉的应用解剖

目的：为带蒂阴茎皮瓣修复尿道下裂提供解剖学基础。方法：对３０例成年男性阴茎的动脉分布进行解剖观察。结果：阴茎背浅动脉的一级分支集中在阴茎的近、中１／３段内，其再分支呈扇形分布于阴茎皮肤和包皮。阴茎背浅动脉的分支首先进入包皮外板，经包皮内外板交界处，返折进入内板。阴茎背浅动脉有三种配布类型：①单支分布型（３０％）；②对称分布型（４０％）；③非对称分布型（３０％）。阴茎背动脉在距阴茎冠状沟０．５～１．５ｃｍ范围内发出穿支至包皮内板。结论：用阴茎远侧皮肤和包皮作纵行带蒂岛状皮瓣具有可行性。     

改良袖套式包皮环切术治疗包皮过长28例报告

目的探讨改良袖套式包皮环切术治疗包皮过长患者的疗效。方法采用改良袖套式包皮环切术治疗包皮过长患者28例。术中先标志包皮切除长度,在直视下于包皮内、外板作两个互相平行的环形切口,将两切口间包皮条用小圆头刀锐性剥离,保留完整肉膜及皮下浅层血管,并保留完整的包皮系带。结果28例术中出血极少,切口整齐,术后伤口无水肿,无继发性出血及感染,均一期愈合,切口瘢痕少,阴茎外形美观。结论改良袖套式包皮环切术对包皮过长患者治疗效果满意。     

环扎法矫治包茎及包皮过长48例报告

的　探索包茎及包皮过长矫治的理想方法。方法　用自行设计的包皮环扎法对包茎及包皮过长进行矫治。结果　４８ 例患者均于术后６ ～８ｄ ,包皮自行枯死脱落,伤口愈合,随访６ 个月至１ 年,形态及功能恢复满意。结论　该方法操作简单、创伤小、出血少、疼痛轻、包皮创缘整齐,是整形包皮的有效方法。     

Sensory innervation of the human male prepuce: Meissner's corpuscles predominate

Meissner's corpuscles are the most abundant sensory corpuscles in the glabrous skin of the male prepuce. They are type I, rapidly adapting, low-threshold mechanoreceptors, and their function is linked to the expression of the mechanoprotein piezo-type mechanosensitive ion channel component 2 (PIEZO2). Stimulation of genital Meissner's corpuscles gives rise to sexual sensations. It has been recently demonstrated that digital Meissner's corpuscles, Meissner-like corpuscles, and genital end bulbs have an endoneurium-like capsule surrounding their neuronal elements; that is, the axon and glial lamellar cells, and their axons, display PIEZO2 immunoreactivity. It is unknown whether this is also the case for preputial Meissner's corpuscles. Furthermore, the expression of certain proteins that have been found in Meissner's corpuscles at other anatomical locations, especially in the digits, has not been investigated in preputial Meissner's corpuscles. Here, we used immunohistochemistry to investigate the expression of axonal (neurofilament, neuron-specific enolase), glial (S100 protein, glial fibrillary acidic protein, vimentin), endoneurial (CD34), and perineurial (glucose transporter 1) markers in the preputial and digital Meissner's corpuscles of male participants aged between 5 and 23 years. Furthermore, we investigated the occurrence of the mechanoprotein PIEZO2 in male preputial Meissner's corpuscles. Human male prepuce contains numerous Meissner's corpuscles, which may be grouped or isolated and are regularly distributed in the dermal papillae. Lamellar glial cells display strong expression of S100 protein and vimentin but lack expression of glial fibrillary acidic protein. In addition, they show axonal PIEZO2 expression and have an endoneurial capsule, but no perineurial. Our results indicate that human male preputial Meissner's corpuscles share the immunohistochemical profile of digital Meissner's corpuscles, which is considered to be necessary for mechanotransduction. These data strongly suggest that the structure and function of Meissner's corpuscles are independent of their anatomical location.     

包皮除去环在环切包皮术中的应用研究

治疗包皮过长传统的方法是行包皮环切[1,2]。这种术式创伤大,出血多,术后包皮水肿、疼痛明显、切口感染粘连,缝线反应硬结,拆线痛苦等,影响生活质量。近年来,我们用一次性包皮除去环行包皮环切,效果满意,现报道如下。资料与方法一、一般资料2003年1月-2005年1月,将因包皮过长来     

阴茎拉直衡量去皮法在成人包皮环切术中的应用探讨

目的:研究寻找一种在包皮环切术中衡量去皮适度的最佳方法。方法:对2010年4月~2014年5月收治的220例成人包皮过长患者分别采用传统的包皮环切术及阴茎拉直衡量去皮法包皮环切术。术后观察对比阴茎外观、水肿、伤口恢复、功能及勃起疼痛情况。结果:阴茎拉直衡量去皮法包皮环切术患者术后水肿、外形及勃起疼痛明显好于传统包皮环切术。结论:阴茎拉直衡量去皮法包皮环切术是一种简单、有效的术中衡量包皮去皮量多少的较理想方法,值得临床推广。     

Foreskin development before adolescence in 2149 schoolboys

BACKGROUND: We examined the external genitalia of 2149 elementary schoolboys in the suburban area of Taichung in Taiwan for an understanding of foreskin development before adolescence. METHODS: The study's subjects comprised 692 first-grade boys, 725 fourth-grade boys, and 732 seventh-grade boys. The foreskin's condition was classified as: type I (normal prepuce), type II (adhesion of prepuce), type III (partial phimosis), type IV (phimosis) and type V (circumcised foreskin). Other abnormalities of the genitalia also were recorded. All of the examinations were performed by the same urologist. RESULTS: The incidence of type I foreskin was 8.2% in first-grade boys, 21.0% in fourth-grade boys, and 58.1% in seventh-grade boys. The incidence of type IV foreskin was 17.1% in first-grade boys, 9.7% in fourth-grade boys, and 1.2% in seventh-grade boys. Only one boy had balanoposthitis. Other abnormalities included inguinal hernia (n = 2), hydrocele (n = 12), cryptorchitism (n = 8), varicocele (n = 22), and subcoronal-type hypospadia (n = 1). CONCLUSIONS: Physiological phimosis declines with age. Most boys with phimosis in this study did not require treatment.     

包皮中人乳头瘤病毒基因的检测

了解人乳头瘤病毒（HPV）在正常包皮中的感染及感染型别，来分析HPV与阴茎癌的发生关系。采用PCR技术对48例包皮环切患者的包皮组织进行HPV感染相关性研究及分型。20／48例HPV阳性，阳性率为41．7％，其中HPV11、16、18型阳性率分别8．3％（4／48）、12．8％（6／48）、22．9％（11／48），未见HPV6型。包皮垢或包皮炎患者也有HPV11、16、18型感染。正常包皮中有HPVDNA存在且多为高危型，并伴有包皮垢或既往包皮炎等局部理化刺激因子，为HPV感染与阴茎癌的发生有密切关系提供了佐证。